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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: β2GP I antibodies in complexes with β2GP I as mediators of platelet activationthe apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activationPlatelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression andanti-β2GP I /β2GP I complex was able to activate platelets, and this activationResults showed that the anti-β2GP I /β2GP I complex induced platelet activation

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Furthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation.

Keywords： anti-   

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Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 236-238 doi: 10.1007/s11684-017-0611-y

Abstract:

Recently, Ng . reported that the A:T>T:A substitutions, proposed to be a signature of aristolochic acid (AA) exposure, were detected in 76/98 (78%) of patients with hepatocellular carcinoma (HCC) from the Taiwan Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide changes. However, other carcinogens, e.g., tobacco carcinogens 4-aminobiphenyl and 1,3-butadiene, air toxic vinyl chloride and its reactive metabolites chloroethylene oxide, melphalan and chlorambucil, also cause this signature in the genome. Since tobacco smoke is a worldwide public health threat and vinyl chloride distributes globally and is an air pollutant in Taiwan Province, the estimation of the patients’ exposure history is the key to determine the “culprit” of the A:T>T:A mutations. Apparently, without estimation of the patients’ exposure history, the conclusion of Ng is unpersuasive and misleading.

Keywords： genomic signature     carcinogen     aristolochic acid     tobacco smoke     vinyl chloride     hepatocellular carcinoma    

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Extracts from cotton over the whole growing season induce

Ming LANG, Rui YU, Yongqing MA, Wei ZHANG, Christopher S. P. McErlean

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 2,   Pages 228-236 doi: 10.15302/J-FASE-2017150

Abstract: Extracts of cotton across the whole growing season were able to induce germination but displayed significant

Keywords： agricultural systems     cotton     crop ecology     crop rotation systems     weed management    

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Enhanced activation of peroxymonosulfate by CNT-TiO

Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 5, doi: 10.1007/s11783-019-1161-0

Abstract: In this work, a UV-light assisted peroxymonosulfate (PMS) activation system was constructed with theirradiation, the photoinduced electrons generated from TiO2 could be continuously transferred to CNT for the activationcatalytic performance was ascribed to the introduction of photoinduced electrons, which could enhance the activation

Keywords： Peroxymonosulfate activation     Carbon nanotubes     TiO2     Water treatment    

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Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation Article

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Engineering 2021, Volume 7, Issue 10,   Pages 1415-1425 doi: 10.1016/j.eng.2020.08.013

Abstract: Exosomes derived from pancreatic cancer cells tend to be enriched in proteins that are anchored to theFor the first time, our study has demonstrated that CD44, a transmembrane glycoprotein delivered by exosomesthereby remodeling intracellular skeleton proteins, and to promote tumor cell motility through the activationCD44–α6β4 complex can be delivered to the target region via the paracrine effects of exosomesThe selective uptake of CD44-competent tumor exosomes by liver cells activated fibrotic pathways and

Keywords： Pancreatic cancer     Organotropic metastasis     Exosomes     Pre-metastatic niche     CD44    

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Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 387-394 doi: 10.1007/s11705-022-2250-3

Abstract: straightforward and effective strategy is presented for producing highly porous carbons via a self-activation

Keywords： self-activation     zinc organic salts     abundant mesopores     symmetric supercapacitor     liquid electrolyte    

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Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 545-554 doi: 10.1007/s11708-023-0867-7

Abstract: The effect of oxygen vacancies on the adsorption and activation of CO2 on the surface of differentThe calculations show that the oxygen vacancies contribute greatly to both the adsorption and activationFurthermore, the activation of CO2 on the ZrO2 surface where oxygen vacancies areThis finding demonstrates that the presence of oxygen vacancies promotes the activation of CO2

Keywords： CO2 activation     oxygen vacancies     ZrO2     different phases    

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A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1485-1492 doi: 10.1007/s11705-022-2169-8

Abstract: Methane activation is a pivotal step in the application of natural gas converting into high-value addedIn present work, methane activation on MgO supported Ni–M (M = Fe, Co, Cu, Pd, Pt) cluster was exploredDoping elements of the same period in Ni cluster, such as Fe, Co and Cu, for C–H bond activation followsIn addition, doping the elements of the same family, like Pd and Pt, for CH4 activation isConsequently, C–H bond activation demands a lower energy barrier on Ni–Pt cluster.

Keywords： CH4 dissociation     Ni–M     C–H bond activation     charge transfer    

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Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves

S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR

Frontiers in Energy 2016, Volume 10, Issue 4,   Pages 409-423 doi: 10.1007/s11708-016-0431-9

Abstract: This paper proposes an optimal dynamic reserve activation plan after the occurrence of an emergency situationThe proposed reserve activation approaches are solved using the genetic algorithm, and some of the simulationThese results demonstrate the advantage of the proposed integrated/dynamic reserve activation plan over

Keywords： demand-side reserves     dynamic reserve activation approach     hydro power units     post contingency     sequentialreserve activation approach     spinning reserves    

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract: We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomesFurthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes

Keywords： liquid biopsy     circulating tumor cells     cell-free ctDNA     exosomes     precision medicine    

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Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 85-90 doi: 10.1007/s11684-016-0435-1

Abstract:

Leukocyte activation has been linked to atherogenesis, but there is little in vivo We evaluated the predictive value for progression of coronary artery disease (CAD) of leukocyte activation

Keywords： coronary artery disease     inflammation     integrin     myeloperoxidase     leukocyte activation    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: Melanoma is the most aggressive cutaneous tumor. Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis. However, the functional significance of NETO2 in melanoma progression remains unclear. Herein, we found that NETO2 expression was augmented in melanoma clinical tissues and associated with poor prognosis in melanoma patients. Disrupting NETO2 expression markedly inhibited melanoma proliferation, malignant growth, migration, and invasion by downregulating the levels of calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling pathway. By contrast, NETO2 overexpression had the opposite effects. Importantly, pharmacological inhibition of CaMKII/CREB activity with the CaMKII inhibitor KN93 suppressed NETO2-induced proliferation and melanoma metastasis. Overall, this study uncovered the crucial role of NETO2-mediated regulation in melanoma progression, indicating that targeting NETO2 may effectively improve melanoma treatment.

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1706-0

Abstract:

● A CNT filter enabled effective KMnO4 activation via

Keywords： KMnO4     Carbon nanotubes     Non-radical pathway     Electron transfer     Water treatment    

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Title Author Date Type Operation

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Carcinogens that induce the A:T>T:A nucleotide substitutions in the genome

Guangbiao Zhou, Xinchun Zhao

Journal Article

Extracts from cotton over the whole growing season induce

Ming LANG, Rui YU, Yongqing MA, Wei ZHANG, Christopher S. P. McErlean

Journal Article

Enhanced activation of peroxymonosulfate by CNT-TiO

Xuemin Hao, Guanlong Wang, Shuo Chen, Hongtao Yu, Xie Quan

Journal Article

Integrin α6β4 to Support Organotropic Metastasis via Regulating Tumor Cell Motility and Target Host Cell Activation

Wei Mu, Yajie Xu, Pengfei Gu, Wenbo Wang, Jingquan Li, Yang Ge, Hui Wang

Journal Article

Hierarchical porous carbon derived from one-step self-activation of zinc gluconate for symmetric supercapacitors

Journal Article

Enhanced performance of oxygen vacancies on CO adsorption and activation over different phases of ZrO

Journal Article

A density functional theory study of methane activation on MgO supported NiM cluster: role of M on C–Hactivation

Journal Article

Optimal dynamic emergency reserve activation using spinning, hydro and demand-side reserves

S. Surender REDDY,P. R. BIJWE,A. R. ABHYANKAR

Journal Article

Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Journal Article

Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A. de Vries,Arash Alipour,Erwin Birnie,Andrew Westzaan,Selvetta van Santen,Ellen van der Zwan,Anho H. Liem,Noëlle van der Meulen,Manuel Castro Cabezas

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Insights into the electron transfer mechanisms of permanganate activation by carbon nanotube membrane

Journal Article